This Consensus Statement provides a nomenclature framework and experimental recommendations for studying mitochondrial transfer and transplantation.

This Review provides an overview of the biology of amylin and highlights opportunities, as well as challenges, in the development of amylin-based drugs for the treatment of cardiometabolic diseases.

In this Review, the authors provide a detailed overview of insulin signalling and its dysfunction, highlighting new therapeutic opportunities.

Nshanian et al. investigate the differential effects of the short-chain fatty acids propionate and butyrate on chromatin remodelling and gain insight into the mechanisms that drive selective histone acylation.

Temporal profiling of central carbon metabolism during Kras^G12D-driven acinar-to-ductal metaplasia reveals that disruptions in NADPH-producing enzymes accelerate the formation of pancreatic precancerous lesions.

In the early stages of pancreatic ductal adenocarcinoma (PDAC) development, loss of ALDH1L2 expression elevates reactive oxygen species levels, driving accelerated acinar-to-ductal metaplasia. Decreased ALDH1L2 expression is accompanied by formate overflow, which can be used to monitor PDAC progression.

The authors provide an interactive resource of folate one-carbon metabolism in 37 tissues in germ-free and conventional mice.

Using single-cell tissue imaging and spatial proteomics to study mitochondria–lipid droplet coupling in hepatocytes, PLIN5 phosphorylation is identified as a mediator of lipid flux and nutrient stress responses.

DGAT1 controls sex-specific CD8⁺ T cell responses in tumours, reducing mitochondrial function and tumour control in female mice, but protecting against oxidative stress and tumour growth in male mice through androgen receptor signalling.

Leveraging pythons as an extreme model of feeding and fasting behaviour, this study uncovers para-tyramine-O-sulphate as a conserved postprandial metabolite that links nutrient intake to energy balance by activating hypothalamic neurons and suppressing food intake in pythons and mice.

Although long-chain acyl-CoA esters are essential to virtually every aspect of lipid metabolism, their regulatory and signalling roles remain underappreciated. These molecules deserve far greater attention than they receive, because their spatially restricted formation and tightly regulated abundance endow them with potent and highly specific metabolic cues.

Incretin-based therapies have revolutionized the treatment of obesity and related metabolic disorders. On World Obesity Day (4 March), we discuss incretin-based therapies as go-to treatments for obesity and its comorbidities, highlighting triumphs and cautionary tales.

Adjusting energy expenditure for body composition and visualizing the results are key to understanding the role of energy expenditure in human physiology and disease. Here, we outline specific analysis of covariance modelling and the design of partial residual plots optimized for analysing human energy expenditure data.

The glucagon-like peptide 1 receptor agonist (GLP-1RA) class of medicines has emerged as transformative for the treatment of diabetes, obesity and other diseases. On the twentieth anniversary of the approval of exenatide (Byetta), three former employees of Amylin Pharmaceuticals acknowledge the contributions of some of the individuals and the innovation responsible for delivering the first approved GLP-1RA — the forerunner to the modern blockbuster drugs.

Social media has become a go-to source for nutritional advice, and a space in which influencers compete with, and often drown out, evidence-based guidance. The scientific community should counter this viral spread of misinformation by making trustworthy information more accessible.