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This issue explores how digital technologies are reshaping evidence generation and reflects on the underlying evidence for clinical decision-making in dentistry. The editorial introduces the concept of a “dental-friendly menu” and asks the question: do we need to start asking new questions in dentistry? The research articles examine emerging digital innovations, including the potential role of digital twin technologies in dentistry, the shift from traditional systematic reviews to dynamic, real-time evidence systems, and the growing integration of artificial intelligence, digital diagnostics, and teledentistry for the early detection of dental caries. Alongside these developments, a series of reflections evaluate the evidence behind commonly discussed interventions and technologies, from biomaterials following third molar extraction and low-level laser therapy in oral surgery to implant design, postoperative pain management, and AI-supported orthodontic decision-making. Together, these papers highlight the opportunities and ongoing uncertainties surrounding digital innovation and evidence-informed clinical practice in contemporary dentistry.