Source: (Journal of visualized experiments : JoVE) Plasma proteomics via mass spectrometry enables biomarker discovery for systemic diseases. Advances in high-throughput technologies improve protein identification and quantification, addressing past limitations like poor reproducibility. The study presents a scalable workflow integrating immunodepletion, filtration, and LC-MS/MS profiling, enhancing proteome depth and reducing variability. This method supports accurate differential protein expression analysis, aiding biomarker-driven diagnostics and personalized medicine.
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