When I put one tblr environment in another there is an alignment problem, it is centered when it should not as you can see in the example below.
\documentclass{article}
\usepackage{tabularray}
\usepackage{amsmath}
\begin{document}
tblr in tblr :
\[ \begin{tblr}{cr@{\ }c@{\ }l}
& \det( \overrightarrow{AM};\overrightarrow{AB}) &=& 0 \\
\iff& \begin{tblr}{|cc|} x-1 & -3 \\ y+3 & 4 \\ \end{tblr} &=& 0 \\
\iff& 4(x-1) + 3(y+3) &=& 0 \\
\end{tblr}\]
array in tblr :
\[ \begin{tblr}{cr@{\ }c@{\ }l}
& \det( \overrightarrow{AM};\overrightarrow{AB}) &=& 0 \\
\iff& \begin{array}{|cc|} x-1 & -3 \\ y+3 & 4 \\ \end{array} &=& 0 \\
\iff& 4(x-1) + 3(y+3) &=& 0 \\
\end{tblr}\]
\end{document}


tblrin this case. And I don't think that nestingtblris supported.+vmatrixenvironment but I simplified it for the example.