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A robotic, cell–free platform rapidly prototypes redesigned genetic codes, enabling the translation of proteins with reassigned codons and non-standard amino acids without altering living genomes.
Comparative and functional analyses of Myotis bats uncover unique patterns of adaptation in virus-interacting proteins and longevity-associated pathways, linking two hallmarks of bat biology.
Malva enables ultrafast, reference-free searching of raw single-cell sequences across millions of cells, transforming static transcriptomic atlases into dynamic resources for understanding the functions of sequences.
Single-cell RNA-sequencing shows that cell-type-specific expression quantitative trait loci drive much of complex trait heritability, highlighting cell-type-specific gene regulation as key to linking genetic variants with traits.
Restudy of a challenging fossil using cross-polarized light imaging and phylogenetic reconstruction identifies Chosha praecursor, a probable early-diverging insect, helping to bridge the longstanding ‘hexapod gap’ in the fossil record.
Quantum oscillation measurements map the g-wave altermagnetic order parameter in CrSb, establishing it as a prototypical unconventional magnet with momentum-dependent spin splitting.
Analysis of tracking data from Mars orbiters reveals time-variable gravity field behaviour reflecting the structure underlying the Martian crustal dichotomy and indicates the preservation of a 200–400 °C thermal anomaly in the present-day mantle below the southern highlands.
Efficient degradation of fucoidans depends on complementary bacterial guilds that cooperatively break backbone and side-chain sugars, revealing a conserved, globally relevant mechanism that shapes marine carbon cycling.
A binding-to-release drug conjugate strategy enables targeted payload release without cellular internalization, improving tumour specificity, efficacy and expanding therapeutic targets beyond conventional drug conjugates.
Observations from natural volcanic watersheds demonstrate attenuation of alkalinity fluxes along the complete reactive pathways from soil to river that lead to reductions in exported alkalinity, indicating the limiting effects of critical zone processes.
The kine neural reconstruction algorithm produces high-resolution, time-continuous very long baseline interferometry videos, enabling direct measurement of instantaneous plasma velocities and detailed kinematic analysis of relativistic astrophysical jets.
A key role for retrograde neuromodulatory signalling in motivated behaviour is shown through dynamic endocannabinoid release within a thalamostriatal circuit that regulates behavioural engagement during reward seeking.
Cryogenic electron microscopy structures of full-length human UGCG, the gatekeeper that dictates the scale and composition of glycosphingolipid diversity, are reported, showing that it uses a metal-independent catalytic mechanism driven by an arginine network.
Simultaneous imaging of premotor cortex and cerebellar granule cells in mice learning two skills in parallel shows that trajectories generalize in cortex but coherently reorient apart in granule cells, supporting generalization and separation between contexts.
Single-molecule long-read sequencing of human sperm reveals variation in recombination across donors and that a substantial fraction of non-crossover gene conversions arises before meiosis, distinct from PRDM9-driven recombination and associated with fragile sites.
Non-destructive single-molecule absorption spectroscopy is achieved by detecting photon recoil from a trapped molecular ion, enabling single-photon-sensitive measurements of molecular vibrational transitions.
