Cancer Gene Therapy

Welcome to Cancer Gene Therapy

The essential gene and cellular therapy resource for cancer researchers and clinicians.

Featured

Application of CAR-T therapy in solid tumors: current opportunities and challenges

Aixin Wang
Xinyu Ye
Chao Zhang
Review Article27 Apr 2026
Landscape and functional impact of variants of unknown significance of immune response genes in human cancer

Cristina A. Diaz
Juan M. Morillas
Montse Sanchez-Cespedes
Brief Communication04 Apr 2026
The TCR in CAR T cell therapy: use it or lose it?

Olivia Liseth
Richard Vile
ArticleOpen Access24 Mar 2026
Memory programming and new manufacturing paradigms in CAR-T cell therapy

Niloufar Mohammadkhani
Saber Ebrahimi
Mansour Poorebrahim
Review Article15 Mar 2026

Current issue

WTAP stabilized by USP7 contributes to enzalutamide resistance in prostate cancer via mediating AKT m⁶A-modification

Ruxue Shi
Kai Gu
Qingxia Hu
ArticleOpen Access14 Apr 2026
Ataxia-telangiectasia mutated kinase inhibition overcomes gemcitabine resistance in intrahepatic cholangiocarcinoma via DNA ligase I-dependent repair vulnerability

Sheng-Hsuan Lin
Yi-Ru Pan
Chun-Nan Yeh
ArticleOpen Access07 Feb 2026
AP-1 promotes oncogenic transcription in lung cancer cells by bridging promoter-enhancer interactions

Xianglong Tan
Michael Kroneberg
Michael F. Carey
ArticleOpen Access03 Dec 2025
Clathrin-associated SCYL2 contributes to the activation of PI3K/AKT signaling and tumorigenesis through PTEN phosphorylation in adult T-cell leukemia/lymphoma

Tomonaga Ichikawa
Shunsuke Shimosaki
Kazuhiro Morishita
ArticleOpen Access16 Feb 2026
Therapeutic advances with KRAS^G12C inhibitors and combination strategies in non-small cell lung cancer brain metastases

Debanjan Bhattacharya
Benjamin Roman
Sanjana Reddy
Review ArticleOpen Access09 Feb 2026
Pleiotropic mechanisms of cancer-associated fibroblast-mediated resistance in hepatocellular carcinoma: emerging therapeutic vulnerabilities and targeting strategies

Wei Xie
Jingjing Fang
Changquan Ling
Review Article14 Feb 2026

Contents

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Announcements

Follow CGT on LinkedIn

Keep up to date with the latest news and research from CGT via LinkedIn
New Editor-in-Chief - Leandro Castellano

As of January 1st 2026, we welcome Leandro Castellano as the new Editor-in-Chief of Cancer Gene Therapy. We thank Georgios Giamas for his excellent leadership over recent years but look forward to this exciting new partnership.
Get your manuscript ready for journal editors

Follow our checklist to avoid common mistakes to help get your manuscript to journal editors faster. We also offer a FREE language check from our partner AJE.
New QC checks introduced in CGT

As part of CGT’s continuous effort to provide high quality & innovative research, we have introduced new QC checks: Requirement of a cover letter in an institutional letterhead at first submission; Requirement for institutional e-mail(s) addresses for the corresponding author(s); Inclusion of an Author Contribution statement in the submitted manuscript; Availability of original data upon request

Browse articles

Clinical landscape and development of universal CAR-T cell therapies

Jincai Zhou
Perspective28 May 2026
Single-nucleus and spatial transcriptomics analyses reveal interplay between evolutionary dynamics and energy metabolism in primary cardiac lymphoma

Xiaojuan Wei
Qianbing Zhang
Sipei Wu
Article22 May 2026
The role of STAT3 in regulating ferroptosis in cancer: molecular mechanisms and targeted therapeutic perspectives

Xianglin Jiang
Yatsu Lam
Peihao Yin
Review Article12 May 2026
Dual PI3K/AKT/mTOR and CDK4/6 inhibition suppresses survivin to overcome uterine dedifferentiated endometrial carcinoma

Yun-Hsin Tang
Cheng-Lung Hsu
Chiao-Yun Lin
Article08 May 2026
MSTO1 modulates RAD51 activity to safeguard mitochondrial DNA integrity and control immune responses

Kaiqi Cheng
Zhanzhan Xu
Jiadong Wang
Article07 May 2026
b-AP15 enhances TRAIL-induced cell death in HNSCC via the induction of ROS/JNK/DR5 signalling

Fin T. A. Brown
Lucy Quesne
Ethan L. Morgan
ArticleOpen Access02 May 2026
YTHDF1/SLC39A4 signaling axis promotes gastric cancer cell proliferation by suppressing cuproptosis ex vivo and in vitro

Jingying Su
Jihan Qi
Shizhu Jin
ArticleOpen Access29 Apr 2026
Preclinical development of a mutant KRAS targeting therapeutic cancer vaccine

Catarina Pinto
Romana Bischl
Josipa Raguz
Article28 Apr 2026
Application of CAR-T therapy in solid tumors: current opportunities and challenges

Aixin Wang
Xinyu Ye
Chao Zhang
Review Article27 Apr 2026

In this collection we highlight a selection of articles from 2022, which top the list of the journal’s most cited, downloaded and most shared (including press coverage, blogs, Twitter, Facebook and Weibo). The articles showcase the breadth of scope and coverage that the journal consistently delivers to its readers.

Collection 02 Feb 2023

Welcome to Cancer Gene Therapy

Featured

Application of CAR-T therapy in solid tumors: current opportunities and challenges

Landscape and functional impact of variants of unknown significance of immune response genes in human cancer

The TCR in CAR T cell therapy: use it or lose it?

Memory programming and new manufacturing paradigms in CAR-T cell therapy

Current issue

WTAP stabilized by USP7 contributes to enzalutamide resistance in prostate cancer via mediating AKT m⁶A-modification

Ataxia-telangiectasia mutated kinase inhibition overcomes gemcitabine resistance in intrahepatic cholangiocarcinoma via DNA ligase I-dependent repair vulnerability

AP-1 promotes oncogenic transcription in lung cancer cells by bridging promoter-enhancer interactions

Clathrin-associated SCYL2 contributes to the activation of PI3K/AKT signaling and tumorigenesis through PTEN phosphorylation in adult T-cell leukemia/lymphoma

Therapeutic advances with KRAS^G12C inhibitors and combination strategies in non-small cell lung cancer brain metastases

Pleiotropic mechanisms of cancer-associated fibroblast-mediated resistance in hepatocellular carcinoma: emerging therapeutic vulnerabilities and targeting strategies

Announcements

Follow CGT on LinkedIn

New Editor-in-Chief - Leandro Castellano

Get your manuscript ready for journal editors

New QC checks introduced in CGT

Browse articles

Clinical landscape and development of universal CAR-T cell therapies

Single-nucleus and spatial transcriptomics analyses reveal interplay between evolutionary dynamics and energy metabolism in primary cardiac lymphoma

The role of STAT3 in regulating ferroptosis in cancer: molecular mechanisms and targeted therapeutic perspectives

Dual PI3K/AKT/mTOR and CDK4/6 inhibition suppresses survivin to overcome uterine dedifferentiated endometrial carcinoma

MSTO1 modulates RAD51 activity to safeguard mitochondrial DNA integrity and control immune responses

b-AP15 enhances TRAIL-induced cell death in HNSCC via the induction of ROS/JNK/DR5 signalling

YTHDF1/SLC39A4 signaling axis promotes gastric cancer cell proliferation by suppressing cuproptosis ex vivo and in vitro

Preclinical development of a mutant KRAS targeting therapeutic cancer vaccine

Application of CAR-T therapy in solid tumors: current opportunities and challenges

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Reader's Choice: the best of Cancer Gene Therapy 2022

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Manufacture of tumor- and virus-specific T lymphocytes for adoptive cell therapies

Precise and efficient siRNA design: a key point in competent gene silencing

Recombinant vesicular stomatitis virus targeted to Her2/neu combined with anti-CTLA4 antibody eliminates implanted mammary tumors

The use of hypoxic cultured mesenchymal stem cell for oncolytic virus therapy

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