Chemical Biology #RSCChemBio

📢Issue 5 of RSC Medicinal Chemistry is now online! Check out the research behind the cover and more in this month's issue🔽 The research providing the cover comes from Paul Harris, Margaret Brimble, Alan Cameron & colleagues at the University of Auckland, University of Otago & Victoria University of Wellington introducing CLipPA lipid chemodiversity to enzymatically truncated polymyxin B as a soft drug strategy to combat Gram-negative pathogens 🔗https://lnkd.in/eHRKzAxx Also seen in this issue: A #OpenAccess review exploring the latest developments in modulators, antibody therapy and gene therapy targeting BACE1 by Kagan Kerman et al. from the University of Toronto 🔓https://lnkd.in/eXutndYE Research from Jeffrey Strovel, Steven Fletcher & co. at the University of Maryland conducting lead optimization of 5jc21, a quinolin-2(1H)-one-based inhibitor of the BRD4 member of the BET protein family 🔗https://lnkd.in/e3x5Z-C9 This #OpenAccess paper reporting quinoline/thiazole compounds as selective acetylcholinesterase inhibitors by Zafer Asım Kaplancıklı & colleagues from Anadolu University 🔓https://lnkd.in/evdj6mFv Research from Lei Wang, Engin Umut Akkaya et al. at the Dalian University of Technology describing hypoxia-triggered dichloroacetate delivery for effective reversal of cancer cell reprogramming 🔗https://lnkd.in/ewWAhR_g A #OpenAccess paper exploring a benzothiophene scaffold for use as adjuvants with β-lactam antibiotics against MRSA by Paul Dunman, Christian Melander & co. from University of Rochester & University of Notre Dame 🔓https://lnkd.in/e8bgn278 This review from Philip Thompson & colleagues at Monash University discussing the diverse ring architectures of cyclic peptidomimetics targeting melanocortin receptors 🔗https://lnkd.in/etU59dGh #OpenAccess research on the design, synthesis & anticancer evaluation of novel pyrrole–pyrazoline/chalcone hybrids by Mansour Alturki, Marwa F. Ahmed, Atiah Almalki et al. from Imam Abdulrahman Bin Faisal University, Taif University & King Faisal University 🔓https://lnkd.in/enasf4xW Found these articles interesting? Don't miss the rest of the issue below👇 https://lnkd.in/est9rT52

✨ Don't miss this review from Lydia Eirini Papagora and Stephen Cochrane out now in #RSCChemBio on SOX-labelled peptides for probing kinase and phosphatase activity in real-time assays! ➡️ https://lnkd.in/e-K4vvN7

✨ How do you make peptides that are stable against proteolytic degradation? ➡️ Juan Del Valle and colleagues at the University of Notre Dame are expanding the repertoire of peptide backbone modifications for chemically distinct and minimally perturbing strategies for stable bioactive peptides! 👉 Read it here! https://lnkd.in/erteNGqy

🌿 Don't miss this #RSCChemBio article on a novel natural product, Igalan, which shows promise as an anti-inflammatory agent against sepsis! ✨ Read about how Igalan directly supresses NLRP3 inflammasome activation here: https://lnkd.in/ee7BG5hr #DrugDiscovery

📢 Have you read this #RSCChemBio review from Carsten Schultz and Andrew Emili on the role of acyl-chain remodelling in protein-phospholipid interaction networks and cancer progression? ➡️ Catch it here! https://lnkd.in/eJ-wAn7k #Phospholipids #Proteins

📢 Call for Abstracts: GEM-APPICOM 2026 | At the Confluence of Biomembrane Sciences We are excited to announce that the XXIV GEM and 7th APPICOM Joint Meeting is now accepting submissions! This international conference will bring together scientists from biology, biochemistry, biophysics, chemistry, and physics to discuss the latest advances in #MembraneScience and #Biomembranes. 🔬 Conference Focus Areas • Membrane Mechanics & Remodeling • Structure and Dynamics of Membrane Proteins • Chemical & Biophysical Tools • Interactions with Membranes • Lipid Organization and Dynamics • Membranes at Interfaces • Theoretical & Computational Approaches 📍 Location: Lyon, France 📅 Conference Dates: November 3–6, 2026 ⏳ Submission Deadline: July 1, 2026 Why submit? ·       Present your research to an international community of biophysicists and biologists. ·       Network with experts in biomembranes ·       Early career researchers: poster and presentation prizes 🏆 Find submission guidelines and portal here: gem-2026.sciencesconf.org/ #ConfluenceOfMembraneSciences #GEM2026 #APPICOM #SIBPA #MembraneProteins #LipidMembranes #MembraneBiology #SoftMatter #StructuralBiology #ComputationalBiophysics #Biophysics #ScientificConference #Lyon

Submissions to our upcoming themed collection on Epigenetics and epitranscriptomics are now open! This collection is guest edited by Prof. Arasu Ganesan (Liverpool John Moores University, UK), Prof. Masayuki Sakurai (Tokyo University of Science, Japan), and Prof. Stefanie Kaiser (Goethe University Frankfurt, Germany). Epigenetic and epitranscriptomic modifications have important roles in normal biological function and disease states, and their investigation and control has significance for understanding cell processes and the design of therapeutics. This themed collection aims to draw together research investigating, and manipulating these, including but not limited to small molecule and enzymatic tools, mapping techniques, probes, and editing methods. The submission deadline is 30 September 2026. Find out more on our blog post: : https://lnkd.in/gxgbvQxM 

Don't miss this year's Gordon Research Conferences on Induced Proximity Modalities and Therapeutics - "Expanding Proximity Driven Pharmacology and Drug Discovery". Our Editorial Board member Michelle Arkin is vice-chairing, and the journal is proud to be sponsoring the meeting. Find out more: https://lnkd.in/eBD5_CWX

📢 Welcome to issue 5 of RSC Chemical Biology! Don't miss the excellent work featured as our cover articles this month. ✨ This issue's outside front cover comes from Sarah M. Spigelmyer and Patricia C. Dos Santos. Read their review on the function and biogenesis of iron-sulfur clusters and the diverse roles that these ancient ubiquitous cofactors play across biochemical processes! 🔓 https://lnkd.in/eY2x77ey ➡️ Also in this issue, find the Editorial on our newest themed collection on Endocytosis and cellular delivery guest edited by alexander kros, Georgina Such and Vincent Rotello 🔓https://lnkd.in/evsxzUsV Find the rest of the collection here: https://lnkd.in/eEjZxf4f 👉 Don't miss other articles artificial nucleic acids, lipoprotein trafficking, DNA damage repair, protein-protein interaction inhibitors and more! 📢 All these articles and the rest of the issue can be found free to read here: https://lnkd.in/e9Y6vdRP #RSCChemBio #OpenAccess

Early bird registration for Directing Biosynthesis closes on 18 May. Join your community for a day of cutting-edge research, connect with colleagues and leading experts, including: - Jennifer Andexer, Freiburg University, Germany - Rebecca Buller, Zurich University of Applied Sciences, Switzerland - Dominic Campopiano, University of Edinburgh, UK - Sotirios Kampranis, University of Copenhagen, Denmark - Chaitan Khosla, Stanford University, US - Bradley Moore, Scripps Institution of Oceanography, US - Sarah O'Connor, Max Planck Institute for Chemical Ecology, Germany - Mohammad R. Seyedsayamdost, Princeton University, US - Eriko Takano, University of Manchester, UK - Tilman Weber, Technical University of Denmark, Denmark Register now to save £50 ▶️ rsc.li/dbviii