I can not emphasize enough how much I agree with Dr. Samir Mitragotri! At VeriSIM Life, we believe drug failure is rarely about target selection alone. It is about #translation. Most discovery platforms stop at binding affinity or chemical optimization. We go further. We interrogate how a molecule behaves inside real human biological systems, how it distributes, how it is metabolized, how formulation alters exposure, and how delivery determines whether it ever reaches the tissue that matters. Derisking must happen before the clinic, not inside it. That means integrating mechanism, formulation science, pharmacology, and AI/computational modeling into one unified translational framework. Not just predicting if a drug should work, but whether it actually will. That distinction does not guarantee success, but it reduces avoidable failure before capital and patients are put at risk. #biotech #intergratedsystems #translationalsuccess
Roughly 2,000 new molecules enter clinical testing worldwide each year. Yet the pace of drug discovery has not been matched by equivalent efforts in how they are delivered. Delivery technology is not merely an enabling tool; it can fundamentally determine therapeutic success. In many cases, an established molecule combined with an advanced delivery strategy can achieve greater efficacy, safety, and patient benefit than a newly discovered compound lacking such innovation. An exclusive focus on discovering new drugs, without comparable investment in unlocking the therapeutic potential of existing ones through delivery science, represents a missed opportunity. The consequences are substantial: unrealized health gains, avoidable development costs, and delayed societal benefit. Advancing drug delivery should be viewed not as incremental optimization, but as a central pillar of modern therapeutics. American Association of Pharmaceutical Scientists (AAPS) | @aapscomms, Controlled Release Society, Wyss Institute at Harvard University, AIChE - American Institute of Chemical Engineers, Biomedical Engineering Society National Academy of Engineering
Cinnova Technologies, LLC•806 followers
1moInsightful. Jo Varshney