Advanced Research Projects Agency for Health (ARPA-H)

AI is developing rapidly, so we need the right approach for adoption and oversight, especially to trust healthcare AI in real-world settings. During the HIMSS Conference, ARPA-H Program Manager Dr. Haider Warraich underscored the tension in clinical AI: systems that rely fully on human oversight “won’t be able to scale,” but “a system that has no human oversight would be unacceptable.” That’s why ARPA-H is investing in ADVOCATE—a program to develop clinical AI agents that can help guide cardiovascular disease care, paired with a supervisory agent designed to optimize human oversight and ensure these tools continue to perform safely and effectively. For patients and clinicians, this kind of investment is what will help turn promising AI into trusted support for chronic disease management—expanding access, strengthening care teams, and delivering measurable impact at scale. https://lnkd.in/eY-fq4m5 Haider Warraich Healthcare IT News

CIRCLE this date on your calendar! 📆 Are you ready to save lives by empowering ICU teams with AI-powered digital twin technology? Then, don’t miss your chance to submit a solution summary for our Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) program by March 30 at 1pm ET. Learn more:  https://lnkd.in/eS2-Ui2J  

🚨 The bad news: In the past year, hackers have suspended care in American health clinics and disrupted medical device networks nationwide. A fictional hospital ransomware attack is even causing havoc on HBO’s #ThePitt.    🛟The good news: ARPA-H is on the case! Learn how we’re taking on the challenge of modernizing health cybersecurity—with cutting-edge autonomous patching & “digital lifeboats” that bring systems back online in minutes, not days. https://lnkd.in/eCHd6eKa   

Incremental progress will not deliver meaningful improvements in health outcomes. Advancing care requires speed, bold ideas, and the ability to translate breakthrough science into real-world impact.    Director Alicia Jackson joined leaders in business and policy at the Hill & Valley Forum to discuss the immediate steps America must take to ensure we remain a world leader in healthcare.    At ARPA-H, we are working alongside the nation’s top scientists, clinicians, and entrepreneurs to accelerate the development of life-changing therapeutics and bring them to patients faster. Todd Young Zach Weinberg The Hill & Valley Forum

On March 19, U.S. Ambassador Ken Howery joined ARPA-H for a conversation focused on one question: how do we move faster on the toughest problems in health? We traded ideas on pairing ARPA-H’s high-risk, high-reward programs with global expertise in health data and life sciences, and on working together on challenges like antimicrobial resistance and ensuring emerging agentic AI systems help empower patients to take control of their own health. ARPA-H exists to rapidly turn bold ideas into real-world health impact. Connecting that model with international strengths is a powerful way to accelerate what’s possible for patients. 

March 25 is the final day to respond to ARPA-H’s RFI on standardized micro- and nanoplastics. We are seeking organizations with experience producing well-characterized micro- and nano-scale plastic materials for research. If this is your area of expertise, we encourage you to submit a response. https://lnkd.in/e2MFdCfR

More than 2 million Americans are diagnosed with cancer each year. 600,000 will lose their lives. Patients deserve better. ARPA-H’s 1-CURE program is exploring a single, rapid, low-cost radiotherapy designed to treat all cancers — even the hardest to fight. Now it’s your opportunity to help shape what’s next. Join our hybrid Proposers’ Day on March 24 in Houston, TX. Register here: https://lnkd.in/eBNiYQYK

Anyone who has had a loved one enter an ICU knows that critical illness is a formidable challenge. Transforming ICU care to better prevent long-term complications and save millions more lives is exactly the ARPA-H problem we were built to solve. Last week, innovators packed the room at CIRCLE Proposers’ Day to learn more and reimagine the ICU 🏥 Have a bold idea to transform critical care with AI & digital twin tech? Learn more and submit a solution summary by Mar 30: https://lnkd.in/eS2-Ui2J

Sleek new look��same great info! Now is a great time to subscribe to our weekly ARPA-H Vitals newsletter. You’ll find: 💵 Breakthrough funding opportunities 📆 Program timeline reminders 💌 Event & webinar invitations 🎥 Engaging videos 🗞️Latest ARPA-H news Keep your finger on the pulse. Sign up today 📨 https://lnkd.in/ey33rqVR

ICU teams fight hard to help patients survive critical illness. CIRCLE will give them the tools they need to fight smarter. That means AI + digital twin tech to control the body’s immune response in real time when every second counts—saving lives and preventing long-term complications. As CIRCLE Proposers’ Day guest speaker Timothy G. Buchman, PhD, MD said: "If we do this right, the end point is more than just survival. The end point is recovery and to get folks home to their families.” 🎥 Watch the CIRCLE Proposers' Day highlights & learn more: https://lnkd.in/eChMa-UZ.