They have only syntactic difference, run is an extension function while with is not. Here are the definitions (in kotlin-sdlib:1.0.3):
public inline fun <T, R> T.run(block: T.() -> R): R = block() // equivalent to this.block()
public inline fun <T, R> with(receiver: T, block: T.() -> R): R = receiver.block()
Since run is an extension function, it has one more implicit argument of type T, so the argument types are the same. The bodies of the functions are also effectively the same.
Their performance should also be equivalent since both are inline functions: the resulting bytecode should only contain the inlined block body.
The differences in the functions usage are all caused by the fact that run is an extension.
First, run is suitable for calls chaining:
foo.run { bar }.run { baz }
Second, and more important, if a declared variable type has run function with the same signature, it will be called instead of the extension. And run can be shadowed by another extension. This is how extensions are resolved. Example:
class MyClass {
fun <R> run(blockIgnored: MyClass.() -> R): Nothing = throw RuntimeException()
}
"abcdefg".run { println("x") } // prints "x"
MyClass().run { println("x") } // throws RuntimeException
(MyClass() as Any).run { println("x") } // prints "x"
run{}can do the chain call which is good fornullcheck;with{}cannot. That's it.