EMBL Grenoble scientists focus both on fundamental research in structural molecular biology, and on developing state-of-the art instrumentation, methods and services. The research groups at EMBL Grenoble focus mainly on RNA biology and infection biology, in particular the structural molecular biology of protein-RNA complexes involved in gene expression and host-pathogen interactions. The latter includes work on important human viral, parasite and bacterial pathogens. In addition, three technology-focused teams develop and deploy as services to the broader scientific community innovative and automated structural biology technologies related to protein crystallisation, structure determination by X-ray crystallography, small-angle scattering and cryo-electron microscopy methods, as well as ligand screening for drug development.
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Day 4 of #EMBOmacromolecular continuing with such high quality talks from Jörg Standfuss and Arwen Pearson on time resolved crystallography and Jan Kosiński on his spectacular efforts on the nuclear pore complex. EMBL Events EMBO EMBL Grenoble
EMBL Grenoble a republié ceci
Third day of #EMBOmacromolecular got into super resolution microscopy with Jonas Ries followed by single molecule studies from Olivier Duss and wrapped up with SAXS from Melissa Graewert and a fascinating poster session. After practicals on MS and NMR we had a great barbecue - no photos as I was cooking the sausages! EMBL Events EMBL Grenoble EMBO
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Both the 8th Grenoble Cryo-EM Course and EMBO macromolecular practical workshops happened during May. Our very own Oliver Debski-Antoniak and Erika Pellegrini were there with participants, bringing over 20 years of Cryo-EM experience between them across Vitrobot grid prep, sample optimization, and Glacios training. Always great to support the next generation of structural biology researchers. Thanks to EMBL Grenoble, EMBO and Institut de Biologie Structurale (IBS) for having us. #CryoEM #StructuralBiology #SamplePrep #ScientificTraining #Biotech #ALPX
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The first heterodimer predictions are now available in the AlphaFold Database. Almost 80,000 high-confidence heterodimer predictions are openly available in the database, and a further 8.1 million lower-confidence heterodimer predictions are available for bulk download. This follows the addition of millions of predicted homodimer structures to the AlphaFold Database earlier this year. The update focused on 20 of the most studied species, as well as the World Health Organization’s (WHO) priority pathogens list. In the months since, the partnership turned its attention towards analysing heterodimers – protein complexes formed from two different proteins. This achievement is the result of a collaboration between EMBL-EBI, Google DeepMind, NVIDIA, and Seoul National University. A peer-reviewed paper with more details is in the pipeline, so please watch this space. Explore the data in the AlphaFold Database: https://lnkd.in/dzdzkeX
EMBL Grenoble a republié ceci
Second day of #EMBOMacromolecular was great, with talks from Christophe Romier and Martin Pelosse on how to express complexes followed by course stalwart Andrea Sinz on beautiful dynamics revealed by cross linking MS and completed with amazing structures of the flagellum from Gaia Pigino. The afternoon saw EM practicals, all rounded off with dinner in downtown Grenoble. EMBL Events EMBO EMBL Grenoble
EMBL Grenoble a republié ceci
At EMBL, #ARISE fellows are developing innovative technologies and tools for the scientific community across various fields! 🧬 If you need to analyze high-throughput sequencing data, check out Depictio. This easy-to-use, free coding skills tool was developed by ARISE fellow Thomas Weber at EMBL Heidelberg. 🔗 https://lnkd.in/d783sGPC 🧪 Are you analysing the biophysical properties of proteins and other compounds? The #eSPC platform is an excellent resource for you. This user-friendly platform enables the analysis of biophysical properties such as mass, stability, and binding affinities, and was created by Osvaldo Burastero at EMBL Hamburg. 🔗https://lnkd.in/eC7d5jFr 💊 If your work involves protein dynamics and drug development, you should learn about EnsemblFlex. Developed by ARISE alumna Melanie Schneider, this tool makes sophisticated protein flexibility analysis accessible to everyone! 🔗 https://lnkd.in/dYdcKBfa 📄 For those focused on data curation, explore Litsieve, a tool designed for the biocuration of scientific literature, developed by ARISE alumnus Matt Jeffryes at European Bioinformatics Institute | EMBL-EBI. Additionally, you can explore AI-powered tools for RNA literature, such as LitSumm and GoFlowLLM, created by ARISE fellow Andrew Green. 🔗 https://lnkd.in/dN3zKdyA https://lnkd.in/dY2RXGkU 🤖 If you are a structural biologist working on crystal detection, AXIS is an AI-based training system that can automate your crystal screening process. This tool was developed by ARISE fellow Aurélien Personnaz at EMBL Grenoble. 🔗 https://lnkd.in/dNTEX5JB Take a look at these tools, and feel free to reach out to the developers to provide feedback! #researchtools #LifeSciences #innovation
EMBL Grenoble a republié ceci
Just arrived at EMBL Grenoble for giving a lecture on crosslinking mass spectrometry tomorrow in the EMBL course ‘Structural characterisation of macromolecular complexes’. So much looking forward to meeting the participants of this course! 🧪🧬🦠 This is already the fourth time I am giving this lecture and coming back to Grenoble is always fantastic. 🏔️⛰️ EMBL Events
EMBL Grenoble a republié ceci
Great start to #EMBOmacromolecular EMBL Grenoble with flash talks from the students and the first lecture by the inimitable Song Tan followed by our first course dinner. Looking forward to a fascinating week of lectures and practicals! EMBO Institut de Biologie Structurale (IBS) PSB - the Partnership for Structural Biology EMBL Events EMBL
This week and next, we are jointly hosting the EMBO Practical Course on Structural Characterisation of Macromolecular Complexes with the ESRF - The European Synchrotron and the Institut de Biologie Structurale (IBS)! A warm welcome to all the students and speakers who joined us yesterday! They have already begun a busy programme of activities, including lectures, flash talks, hands-on practicals, poster sessions, and some fun social events! We hope you will enjoy your time on campus and in Grenoble – please share your experience with us using the #EMBOMacromolecular hashtag! EMBL Events | EMBL | Matthew Bowler | Sagar Bhogaraju | Montse Soler Lopez | Carlo Petosa | Ana Casañal | Diane Weirich | Kristina Djinovic Carugo
We had a wonderful time at the latest EMBL Fit for Spring event last week! While spring in the Alps is at its peak 🌞 🌳 ⛰️ , we enjoyed our popular activities such as running 🏃 , swimming 🏊 , bouldering 💪 , volleyball 🏐 , cricket 🏏 , badminton 🥍 , spikeball ⚽, and yoga 🧘 , as well as a new activity: an orientation run around the EPN campus 🕵 . We also took time to relax with reflexology and Tui Na massages💆 , and to boost our creativity with painting 🎨 and board games 🎲 . This beautiful week of fun and togetherness ended with our traditional table tennis tournament 🏓 . Last but not least, two EMBL Grenoble teams took part in the EMBL Step Contest. 🚶♂️ The 'Anaerobic Legends: Grenoble Drift' finished second 🥈 , achieving 1,216,411 steps and unlocking the gold award for reaching one million steps – congratulations! An honourable mention goes to the 'ensEMBLe' team, who unlocked the bronze award for reaching 350,000 steps. Thank you to our liaison officer Elise Bralet and to our enthusiastic colleagues who organised an amazing week of activities - Gharbi Sarah, Véronique MAYEUX, Diane Weirich, Anton Popov, Nilton Aranda Neto, Anaïs Lamy, PhD, Vinay Kedare, Jules Van Der Walt, Jonas Mehrens, Jean Poylo, and Nikita Sharaev.